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Instead of Microsoft Defender for Office 365

Best Microsoft Defender for Office 365 Alternatives in 2026

Taken from Cloud Detection and Response Software, where Microsoft Defender for Office 365 is listed too, in the same order.

  1. 1

    Oligo Security

    Oligo Security provides runtime security for applications, cloud workloads, and AI systems.

    • Free plan
    • Linux · Web · API · Self-hosted
    7.8 Club score
  2. 2

    Sysdig Secure

    Sysdig Secure is a cloud-native application protection platform for cloud services, containers, Kubernetes, hosts and serverless environments.

    • Windows · macOS · Linux · Web
    7.6 Club score
  3. 3

    Amazon GuardDuty

    Amazon GuardDuty monitors AWS accounts and workloads for malicious activity and produces security findings for response.

    • Free trial
    • Linux · Web · API
    7.4 Club score
  4. 4

    ARMO Platform

    ARMO Platform is a cloud security platform centered on Kubernetes and runtime data, available through the web or self-hosted deployment.

    • Free plan
    • Web · Self-hosted
    7.1 Club score
  5. 5

    SentinelOne Singularity Cloud Security

    SentinelOne Singularity Cloud Security brings cloud posture, workload, identity, data, and AI security into one platform.

    • Web · iPhone and iPad · Android · API
    6.9 Club score
  6. 6

    Tenable One Cloud Security

    Tenable One Cloud Security, described as Tenable One Cloud Exposure, is a web-based CNAPP for finding and reducing risk across multi-cloud and hybrid environments.

    • Web
    6.6 Club score
  7. 7

    Darktrace / EMAIL

    Darktrace / EMAIL is a cloud email-security product that uses behavioral AI to identify and stop phishing, business email compromise, impersonation and social…

    • Web · API
    6.4 Club score
  8. 8

    Palo Alto Networks Cortex Cloud API Security

    Palo Alto Networks Cortex Cloud API Security discovers, prioritizes, and protects APIs across cloud environments.

    • Linux · Web · API
    6.4 Club score
  9. 9

    Sweet Security

    Sweet Security is a runtime CNAPP and AI security platform for cloud applications, workloads, infrastructure, and AI agents.

    • Linux · Web · Self-hosted
    6.4 Club score
  10. 10

    Wiz Defend

    Wiz Defend provides real-time threat detection, investigation, and response across cloud environments, including AI applications.

    • Web
    6.2 Club score
  11. 11

    FortiCNAPP

    FortiCNAPP is a cloud security product for protecting container, serverless, and Kubernetes workloads.

    • Windows · Linux · Web
    5.8 Club score
  12. 12

    Aqua Security

    Aqua Security provides software for securing development workflows, cloud workloads, containers, and Kubernetes environments.

    • Linux · Web
    5.6 Club score
  13. 13

    Cortex Cloud

    Cortex Cloud is a web-based security offering with hybrid deployment and hybrid cloud coverage.

    • Web
    5.4 Club score
  14. 14

    Carbon Black Workload

    • Windows · Linux · Web
    5.4 Club score
  15. 15

    SUSE NeuVector

    SUSE NeuVector is an open-source Kubernetes security product with a free pricing model and self-hosted deployment.

    • Web
    5.1 Club score
  16. 16

    Sophos Cloud Workload Protection

    Sophos Cloud Workload Protection is a web-accessible service for protecting cloud workloads in hybrid deployments.

    • Web
    5.0 Club score
  17. 17

    Upwind Cloud Detection and Response

    Upwind Cloud Detection and Response is a web-based security product for monitoring activity across multiple cloud environments.

    • Web
    5.0 Club score

The whole list: Cloud Detection and Response Software